(Lodder & Kreger-van Rij) S.A. Meyer & Yarrow (Yarrow and Meyer 1978)
Macroscopic morphology
Colonies on Sabouraud dextrose agar at 25°C are off-white, dull, and smooth. This isolate grows at 42°C but fails to grow on media containing cycloheximide.
On cornmeal following 72 hours incubation at 25°C, rudimentary to no pseudohyphae are seen. Short chains of ovoid blastoconidia may be seen.
Special Notes
Candida inconspicua is frequently mistaken for Candida krusei by macroscopic appearance. In addition, sugar assimilation studies by commercial kits may give results of both C. krusei and C. inconspicua, however microscopic examination can differentiate the two as C. krusei produces abundant pseudohyphae while C. inconspicua does not [1270]. This isolate may be under-reported due to confusion with C. krusei. This species has been implicated in osteomyelitis [2227], oropharyngeal and esophageal candidiasis in HIV positive patients [158], and from the blood (2) and liver (1) of three patients with hematological malignancies [505].
FTL* in vitro susceptibility data
| AMB | 5FC | ITRA | VORI |
|---|---|---|---|
| 0.125 µg/ml=1 | 4 µg/ml=1 | 1.0 µg/ml=1 | 2.0 µg/ml=1 |
| 0.25 µg/ml=1 |
| Drug/N | AMB/2 | 5FC/1 | ITRA/1 | VORI/1 |
|---|---|---|---|---|
| MIC Range | 0.125-0.25 | 4.0 | 1.0 | 2.0 |
| MIC50 | – | – | – | – |
| MIC90 | – | – | – | – |
* Fungus Testing Laboratory unpublished data (NCCLS M27-A2)