Trade & Generic Names & General Features Voriconazole (UK-109,496) is a triazole that is structurally related to fluconazole. It is developed by Pfizer Pharmaceuticals ((E):http://www.pfizer.com(E):) and its clinical use was approved by FDA in May 2002. The trade name of voriconazole is Vfend™. Mechanism(s) of Action As with all azole antifungal agents, voriconazole works principally by inhibition of cytochrome P450 14a-demethylase (P45014DM). This enzyme is in the sterol biosynthesis pathway that leads from lanosterol to ergosterol [1674, 1735]. Compared to fluconazole, voriconazole inhibits P45014DM to a greater extend. This inhibition is dose-dependent [2016]. Susceptibility Patterns Voriconazole has favorable in vitro […]
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