A 66-year-old man with recently diagnosed acute myeloid leukemia (AML) transformed from high-risk hypoplastic myelodysplastic syndrome, presented with neutropenic fever during cycle 1 azacitidine/venetoclax therapy. His course had been complicated by severe pancytopenia requiring multiple transfusions.

A 56-year-old male presented to the emergency department with progressive left-sided abdominal pain for 3 weeks. The pain was sharp, rated 6/10, worsened with bowel movements and palpation, and had no alleviating factors. He had previously seen his primary care physician and completed a course of metronidazole without improvement. He endorsed bright red blood mixed with stool and low-grade fevers over the preceding two days.

A 26-year-old otherwise healthy man, originally from Ethiopia and having recently immigrated from Kenya to Canada, presented with increasing pain, swelling, and discharge from a chronic wound to his lower back. The symptoms had persisted for years following childhood trauma from falling into a well.

A 57-year-old male presented to the emergency department with a 10-day history of left-sided facial weakness and pain. Symptoms began approximately two weeks after his return from a six-month stay in Florida. Associated features included facial asymmetry, impaired lip seal with difficulty drinking through a straw, and headache. He also reported a six-month history of intermittent left-sided otorrhea and otalgia. He denied nausea, vomiting, fever, chills, or visual disturbances.

A 52-year-old Mexican woman with a recently positive HIV antibody assay and no treatment was evaluated in the clinic. She denied any significant medical history. Her symptoms began in June 2024 with a non-dysenteric diarrhea that continued for approximately 3 months and improved without any therapy. 

History: The patient is a 74-year-old Caucasian male from Colorado who is a part time resident of Arizona since 2015. He presented to the outpatient infectious disease clinic with a lesion on the lateral aspect of the right ankle (Figure 1) that had been slowly enlarging in size over the past two years.

A 77 year old immunosuppressed man from the south area of Mexico City, an area with significant humidity, presents with fever and cough. Patient reports that “the walls of the closets and attic of the house have damp areas”. The patient admits that he performed work in the attic of his house intermittently, even with his underlying condition.  He has a diagnosis of myelodysplasic syndrome, and before his symptoms emerged. He reports being treated with azacitidine (Vidaza®) during 10 months followed by cyclophosphamide plus eltrombopag one month before the rising symptoms.

A 23-year-old man, who had received a living related donor renal transplant in 2001 and who was taking mycophenolate mofetil, tacrolimus, and prednisone, underwent facial reconstruction surgery on 12/10/2021 to repair facial fractures sustained in an altercation.

A 34-year-old male, with a history of schizophrenia and multiple self-inflicted abdominal injuries requiring exploratory laparotomies, was transferred from a state medical prison to the emergency department.

History: We present a 69-year-old male with a history of hypertension and a prior history of COVID-19 infection one year ago, who presented to the ER with persistent symptoms of headache, sinus pressure, and progressive left-sided visual loss for one year.

An 88-year-old female with hemochromatosis and cirrhosis presented with persistent left-sided otalgia, decreased hearing, and occipital headaches for several months.

A 69-year-old man with a history of stage IIIB esophageal adenocarcinoma status post chemoradiation presented with a hydropneumothorax complicated by a polymicrobial multidrug resistant empyema.

A 28-year-old man from North Carolina presents with headaches, expressive aphasia, and seizures eight months after diagnosis with Cryptococcus neoformans meningitis. Regarding his initial presentation with Cryptococcus meningitis, he presented with dyspnea, difficulty walking, and expressive aphasia.

History: A 26-year-old healthy female presented to Infectious Diseases for evaluation of a rash that had been present for over one year. The rash first started when she traveled to Bangladesh and had sexual intercourse with a male partner who had a rash on his genitals and buttocks.

A 71-year-old man with a history of sarcoidosis complicated by multisystem involvement (liver, spleen, lung, brain, and lymph nodes), who had been maintained on prednisone (10 mg daily) and adalimumab, presented to our medical facility in late fall with a 3-month (m) history of progressive fatigue and weight loss. 

The patient’s post-transplant course was complex and was most recently (starting in Spring of 2023) complicated by Tandem heart placement for worsening heart failure, bioprosthetic mitral valve replacement, PEA cardiac arrest (requiring about 5 days of  VA-ECMO), AKI needing CRRT, placement of tracheostomy, and pulmonary Mycobacterium abscessus infection.

Mucormycosis is a rare, life-threatening opportunistic infection predominantly affecting the immunocompromised population. In this case, we report a 68-year-old female with no discernible immunocompromising condition, apart from uncontrolled diabetes. She tested positive for influenza A viral infection, accompanied by methicillin-sensitive Staphylococcus aureus (MSSA) pneumonia, and subsequently unfolding pulmonary mucormycosis without rhino-cerebral involvement.

A 47-year-old man with suspected acute leukemia due to leukocytosis, thrombocytopenia, fatigue and night sweats was transferred from an outside hospital to our Department of Hematology for further diagnostics and treatment.

Title: Necrotizing pancreatitis with invasive candidiasis and candidemia due to Candida albicans and pan-echinocandin-resistant Candida glabrata Submitted by: Laman Rahimli MD, Jon Salmanton-García PhD, Prof. Oliver A. Cornely MD, Jannik Stemler MD Institution: University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Cologne, Germany andUniversity of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany. Email: laman.rahimli@uk.koeln.de Date Submitted:  13 March 2023 History:  A 64-year-old man presented to the central emergency department (day 0) with weakness and loss of sensation in his left […]

A 58-year-old male presented to our health system’s walk-in orthopedic clinic complaining of worsening pain and swelling of the third 3rd digit of his left hand.

A 41-year-old man with past medical history of diabetes mellitus type II, osteomyelitis s/p right above knee amputation, myocardial infarction s/p AICD placement, and hypertension presented with a three-day history of worsening headaches, photophobia, fever, and right hip pain.

A 39-year-old female with a past medical history of HTN, morbid obesity, chronic rhinosinusitis, s/p bilateral functional endoscopic sinus surgery (FESS) 8 months ago, presented with a 2-month history of worsening frontal headaches, accentuated by standing position and were accompanied by altered sense of smell and nausea. 

A 70-year-old gentleman was admitted to a German Military Hospital in early January 2022 with multiple lacerations of the head and retrograde amnesia following a fall at his nursing home.

A 59-year-old man was admitted for orthotopic heart transplantation. His past medical history was notable for non-ischemic cardiomyopathy status post implantable cardiac defibrillator (ICD) and prior sternotomy for implantation of a left ventricular assist device (LVAD).

A 54-year-old man status post remote orthotopic heart transplantation for non-ischemic cardiomyopathy complicated by cardiac allograft vasculopathy was admitted for redo orthotopic heart transplantation. 

A 36 year old man presented with progressively worsening headache, associated emesis and new onset altered mental status a few days after being discharged following a prolonged and complex hospitalization for cocaine overdose.

56-year-old man was admitted to an outside hospital with fever, short of breath and hypoxia. COVID-19 was diagnosed in the emergency room. He was treated with remdesivir and dexamethasone along with ceftriaxone and azithromycin.