Background Like many other medications, dosages of antifungal agents may be adjusted in patients with compromised kidney or liver function to minimize potential toxicities associated with drug accumulation. Drug interactions can also require a change in antifungal dosing. Fortunately, the effects of impaired kidney and liver function on antifungal concentrations in the body can be anticipated based on the pharmacokinetic properties of the specific antifungal agent; i.e. its absorption, distribution, and pathway for elimination from the body. In certain situations, measuring the serum drug concentration of an antifungal agent can provide some guidance for dosage adjustment or in the assessment […]
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