Shown are the agents that have been licensed or are under development for use as therapy of the fungal infections of man. Picking the most appropriate agent for a given disease is sometimes complex. To aid in this process, see our discussion of agents of choice and the discussions of the individual mycoses themselves. Mixed into the list are also the many topical agents in use for cutaneous mycoses. Please also see our discussion on
antifungal pharmacology,
nephrotoxicity,
drug dosing in renal and liver dysfunction,
drug interactions,
therapeutic drug monitoring,
cost analysis, and
pharmacoeconomic analysis of antifungal therapy.
| Group | Drugs | Routes | Current Status |
|---|---|---|---|
| Allylamines and other non-azole ergosterol biosynthesis inhibitors | Amorolfine | Topical | Licensed |
| Butenafine | Topical | Licensed | |
| Naftifine | Topical | Licensed | |
| Terbinafine | PO, Topical | Licensed | |
| Antimetabolites | Flucytosine | PO, IV | Licensed. IV form no longer available |
| Azoles | Fluconazole | PO, IV | Licensed |
| Itraconazole | PO, IV | Licensed | |
| Ketoconazole | PO, Topical | Licensed | |
| Posaconazole | PO | Licensed | |
| Ravuconazole | Under Development | ||
| Voriconazole | PO, IV | Licensed | |
| Clotrimazole | Topical | Licensed | |
| Econazole | Topical | Licensed | |
| Miconazole | Topical | Licensed | |
| Oxiconazole | Topical | Licensed | |
| Sulconazole | Topical | Licensed | |
| Terconazole | Topical | Licensed | |
| Tioconazole | Topical | Licensed | |
| Chitin synthase inhibitors | Nikkomycin Z | Parenteral | Under development |
| Glucan Synthesis Inhibitors |
Caspofungin | IV | Licensed |
| Micafungin | IV | Licensed | |
| Anidulafungin | IV | Licensed | |
| Polyenes | Amphotericin B (AmB) | IV, Topical | Licensed |
| AmB Lipid Complex | IV | Licensed | |
| AmB Colloidal Dispersion | IV | Licensed | |
| Liposomal AmB | IV | Licensed | |
| AmB Oral Suspension | PO | Licensed | |
| Liposomal Nystatin | IV | Under Development | |
| Topical Nystatin | Topical | Licensed | |
| Pimaricin | Ophthalmic | Licensed | |
| TNF-a Inhibitors | Infliximab | IV | Licensed |
| Etanercept | IV | Licensed | |
| Adalimumab | IV | Licensed | |
| Certolizumab Pegol | IV | Licensed | |
| Golimumab | IV | Licensed | |
| Other Systemic Drugs | Griseofulvin | PO | Licensed |
| Other Topical Drugs | Ciclopirox olamine | Topical | Licensed |
| Haloprogin | Topical | Licensed | |
| Tolnaftate | Topical | Licensed | |
| Undecylenate | Topical | Licensed | |