(Matsushima) Nirenberg (1976)
Macroscopic morphology
Macroscopic morphology may vary significantly on different media, and descriptions here are based upon growth on potato flakes agar at 25°C with on/off fluorescent light cycles of approximately 12 hours each. Rapid growth. Colonies are initially white, becoming tinged with purple. Reverse colorless to dark purple. Sclerotia may be present and are usually dark blue. Sporodochia rarely formed on PFA but when present are tan to orange. Colonies are usually indistinguishable from those of F. moniliforme [2202], [1630].
Microscopic morphology
Hyphae are septate and hyaline. Conidiophores are medium length, simple or branched. Conidiogenous cells are monophialides and polyphialides. Microconidia are abundant, single-celled and clavate, measure 4.5-10.5 x 1.3-2.5 µm, and are borne from both monophialides and polyphiades in false heads and in chains. Macroconidia may be rare, and are very similar to those see in F. moniliforme. Chlamydoconidia are absent [2202], [1630].
Special notes
Fusarium proliferatum has been reported as an agent of onychomycosis [996] and superficial suppurative thrombophlebitis [1599]. A disseminated infection was cited by Summerbell, and Herbrecht reported the successful treatment of pneumonia due to this agent in a transplant recipient [2195], [1030]. Fusarium proliferatum differs from F. moniliforme by forming chains of microconidia from both mono- and polyphialides.
FTL* in vitro susceptibility data
| AMB | ITRA | VORI |
|---|---|---|
| 2.0 µg/ml=1 | 1.0 µg/ml=1 | 2.0 µg/ml=1 |
| 4.0 µg/ml=1 | 4.0 µg/ml=1 | 4.0 µg/ml=1 |
| >8.0 µg/ml=1 | 8.0 µg/ml=1 |
| Drug/N | AMB/2 | ITRA/3 | VORI/3 |
|---|---|---|---|
| MIC Range | 2.0-4.0 | 1.0->8.0 | 2.0-8.0 |
* Fungus Testing Laboratory unpublished data (NCCLS M38-A)