(Lindner & Genoud) van Uden & H.R. Buckely
Teleomorph:
Pichia fermentans Lodder (1932)
Macroscopic morphology
Colonies on Sabouraud dextrose agar at 25°C are tan to yellow, dull, and slightly wrinkled. This isolate grows at 37°C but fails to grow on media containing cycloheximide. The urease reaction is also negative.
Microscopic morphology
On cornmeal following 72 hours incubation at 25°C, abundant, moderately branched pseudohyphae are seen. True hyphae are not formed. This isolate may be differentiated from C. lipolytica by its failure to growth on media containing cycloheximide [1270].
Special notes
This species has been implicated in bloodstream infections [1774], in infections of patients with hematologic malignancies [1256], and as a cause of arthritis in a patient suffering from alcoholism [2255].
FTL* in vitro susceptibility data
| AMB | CAS | 5FC | FLU | ITRA | VORI |
|---|---|---|---|---|---|
| <0.03 µg/ml=1 | 0.25 µg/ml=4 | <0.125 µg/ml=1 | 0.25 µg/ml=1 | 0.03 µg/ml=2 | 0.03 µg/ml=1 |
| 0.06 µg/ml=2 | 0.5 µg/ml=3 | 0.06 µg/ml=1 | 0.25 µg/ml=1 | ||
| 0.125 µg/ml=2 | 8.0 µg/ml=1 | ||||
| >64 µg/ml=1 |
| Drug/N | AMB/5 | CAS/4 | 5FC/1 | FLU/6 | ITRA/3 | VORI/2 |
|---|---|---|---|---|---|---|
| MIC Range | <0.03-0.125 | 0.25 | <0.125 | 0.25->64 | 0.03-0.06 | 0.03-0.25 |
| MIC50 | * | * | * | * | * | * |
| MIC90 | * | * | * | * | * | * |
* Fungus Testing Laboratory unpublished data (NCCLS M27-A2)