Antifungal Dosage Adjustment in Hepatic Failure A number of antifungals require biotransformation into more water-soluble metabolites by the liver before excretion from the body. Antifungals are also known to have, like many other drugs, potentially toxic effects in the liver that may be enhanced with pre-existing liver disease. Therefore, antifungal therapy must be used in caution in patients with hepatic insufficiency. In terms of drug dosing, patients with moderate to severe hepatic dysfunction often exhibit a decreased capacity to metabolize certain antifungal agents, leading to decreased overall drug clearance, an increase in the plasma/serum area under the concentration curve (AUC), […]
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