(Harrison) S.A. Meyer & Yarrow (Yarrow and Meyer 1978) (1985)
Teleomorph:
(Zopf) Lodder & Kreger-van Rij var. hansenii (1985)
Candida famata var. flareri
(Ciferri & Redaelli) Nakase & Suzuki (1985b)
Teleomorph:
Debaryomyces hansenii var. fabryi (Ota) Nakase & M. Suzuki (1985b)
Macroscopic morphology
Colonies on Sabouraud dextrose agar at 25°C are grayish white to yellowish, dull to shiny, and smooth to wrinkled. The two varieties are distinguished by maximum growth temperature. Debaryomyces hansenii var. hansenii has a maximum growth temperature of 35°C while D. hansenii var. fabryi has a maximum growth temperature of 40°C and no growth on cycloheximide. This species is not distinguishable from several other species on Chromager Candida [1069].
Microscopic morphology
On cornmeal following 72 hours incubation at 25°C, usually no pseudohyphae are evident. Rare strains have rudimentary to well-developed pseudohyphae.
Special notes
Candida famata is an emerging pathogen that has been reported to have decreased susceptibility to amphotericin B [1775], [1776]. This species has been recovered from psoriasis, nails, and wounds [1270], the blood in a stem cell transplant patient [2347], and from the retina [382].
FTL* in vitro susceptibility data
| AMB | CAS | 5FC | FLU | ITRA | VORI |
|---|---|---|---|---|---|
| 0.125 µg/ml=4 | <0.03 µg/ml=5 | <0.125 µg/ml=2 | 0.25 µg/ml=2 | 0.03 µg/ml=3 | <0.015 µg/ml=3 |
| 0.25 µg/ml=3 | 0.25 µg/ml=2 | 2.0 µg/ml=1 | 0.5 µg/ml=4 | 0.06 µg/ml=2 | 0.03 µg/ml=3 |
| >16 µg/ml=1 | 1.0 µg/ml=4 | 0.25 µg/ml=2 | |||
| 2.0 µg/ml=2 | |||||
| 4.0 µg/ml=3 |
| Drug/N | AMB/7 | CAS/8 | 5FC/3 | FLU/15 | ITRA/7 | VORI/6 |
|---|---|---|---|---|---|---|
| MIC Range | 0.125-0.25 | <0.03->16 | <0.125-2.0 | <0.125-4.0 | 0.03-0.25 | <0.015-0.03 |
| MIC50 | * | * | * | 1.0 | * | * |
| MIC90 | * | * | * | 4.0 | * | * |
* Fungus Testing Laboratory unpublished data (NCCLS M27-A2)