(Harrison) S.A. Meyer & Yarrow (Yarrow and Meyer 1978) (1985)

Teleomorph:

(Zopf) Lodder & Kreger-van Rij var. hansenii (1985)
Candida famata var. flareri
(Ciferri & Redaelli) Nakase & Suzuki (1985b)

Teleomorph:

Debaryomyces hansenii var. fabryi (Ota) Nakase & M. Suzuki (1985b)

Macroscopic morphology

Colonies on Sabouraud dextrose agar at 25°C are grayish white to yellowish, dull to shiny, and smooth to wrinkled. The two varieties are distinguished by maximum growth temperature. Debaryomyces hansenii var. hansenii has a maximum growth temperature of 35°C while D. hansenii var. fabryi has a maximum growth temperature of 40°C and no growth on cycloheximide. This species is not distinguishable from several other species on Chromager Candida [1069].

Microscopic morphology

On cornmeal following 72 hours incubation at 25°C, usually no pseudohyphae are evident. Rare strains have rudimentary to well-developed pseudohyphae.

Special notes

Candida famata is an emerging pathogen that has been reported to have decreased susceptibility to amphotericin B [1775], [1776]. This species has been recovered from psoriasis, nails, and wounds [1270], the blood in a stem cell transplant patient [2347], and from the retina [382].

 

FTL* in vitro susceptibility data

AMB CAS 5FC FLU ITRA VORI
0.125 µg/ml=4 <0.03 µg/ml=5 <0.125 µg/ml=2 0.25 µg/ml=2 0.03 µg/ml=3 <0.015 µg/ml=3
0.25 µg/ml=3 0.25 µg/ml=2 2.0 µg/ml=1 0.5 µg/ml=4 0.06 µg/ml=2 0.03 µg/ml=3
>16 µg/ml=1 1.0 µg/ml=4 0.25 µg/ml=2
2.0 µg/ml=2
4.0 µg/ml=3

 

Drug/N AMB/7 CAS/8 5FC/3 FLU/15 ITRA/7 VORI/6
MIC Range 0.125-0.25 <0.03->16 <0.125-2.0 <0.125-4.0 0.03-0.25 <0.015-0.03
MIC50 * * * 1.0 * *
MIC90 * * * 4.0 * *

* Fungus Testing Laboratory unpublished data (NCCLS M27-A2)
 

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