(Anderson) S.A. Meyer & Yarrow (Yarrow and Meyer 1978)

Macroscopic morphology

Colonies on Sabouraud dextrose agar at 25°C are white, smooth and glistening. This isolate grows at 42°C but fails to grow on media containing cycloheximide.

Microscopic morphology

On cornmeal following 72 hours incubation at 25°C, only blastoconidia are observed. Yeast cells are quite small measuring only 2.5-4.0 x 3.0-6.0 µm as compared to C. albicans which measures 3.5-6.0 x 4.0-8.0 µm [1270].

Special notes

Candida glabrata is known for its decreased susceptibility to azoles [1410] but good susceptibility patterns to candins [678], [1688]. Despite the decreased susceptibility to azoles, fluconazole prophylaxis has not contributed to an increased incidence of bloodstream infection caused by C. glabrata [1348]. This species do, however, contribute to mortality in approximately 21% of pediatric patients with bloodstream infections [773]. Although this species may be recovered from virtually all infection sites, recent reports of infection include corneal [37], endocarditis [1392], vaginitis [540], and oral [1882].

FTL* in vitro susceptibility data

AMB CAS 5FC FLU ITRA VORI KETO
0.125 µg/ml=23 0.06 µg/ml=311 <0.125 µg/ml=251 <0.125 µg/ml=4 <0.015 µg/ml=8 <0.015 µg/ml=8 0.06 µg/ml=4
0.25 µg/ml=501 0.125 µg/ml=419 0.25 µg/ml=9 0.25 µg/ml=6 0.03 µg/ml=5 0.03 µg/ml=6 0.125 µg/ml=7
0.5 µg/ml=448 0.25 µg/ml=329 0.5 µg/ml=2 0.5 µg/ml=10 0.06 µg/ml=4 0.06 µg/ml=36 0.25 µg/ml=63
1.0 µg/ml=41 0.5 µg/ml=43 2.0 µg/ml=1 1.0 µg/ml=24 0.125 µg/ml=45 0.125 µg/ml=102 0.5 µg/ml=53
2.0 µg/ml=11 1.0 µg/ml=10 4.0 µg/ml=3 2.0 µg/ml=140 0.25 µg/ml=116 0.25 µg/ml=234 1.0 µg/ml=42
4.0 µg/ml=2 2.0 µg/ml=6 8.0 µg/ml=2 4.0 µg/ml=421 0.5 µg/ml=158 0.5 µg/ml=134 2.0 µg/ml=27
16 µg/ml=2 4.0 µg/ml=6 16 µg/ml=1 8.0 µg/ml=375 1.0 µg/ml=179 1.0 µg/ml=89 4.0 µg/ml=6
8.0 µg/ml=3 16 µg/ml=229 2.0 µg/ml=76 2.0 µg/ml=61 8.0 µg/ml=2
>16 µg/ml=10 32 µg/ml=127 4.0 µg/ml=79 4.0 µg/ml=71
>64 µg/ml=199 >8.0 µg/ml=112 >8.0 µg/ml=19

 

Drug/N AMB/1028 CAS/1138 5FC/266 FLU/1535 ITRA/782 VORI/781 KETO/204
MIC Range 0.125->16 0.06->16 <0.125-16 <0.125->64 <0.015->8.0 <0.015->8 0.06-8
MIC50 0.25 0.125 < 0.125 8.0 1.0 0.5 0.5
MIC90 0.5 0.25 < 0.125 > 64 8.0 4.0 2.0

* Fungus Testing Laboratory unpublished data (NCCLS M27-A2)
 

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