Guého & M.Th. Smith (Guého et al. 1992b)
Macroscopic morphology
Colonies on Sabouraud dextrose agar at 25°C are cream colored, glistening, strongly elevated and become cerebriform in the center but maintain smooth margins. The agar often cracks adjacent to the colony. Colony size is 13-17 mm after 7 days incubation.
Microscopic morphology
On cornmeal following 72 hours incubation at 25°C, it produces true hyphae that disarticulate into rectangular arthroconidia. Appressoria are not formed [928, 1270].
Special notes
This isolate is urease positive, grows on media containing cycloheximide and at 37°C, but fails to grow at 42°C. The type strain was isolated from the CSF of a patient with meningitis. It has been involved in a cluster of cases in children associated with a faulty bronchoscope[2112], recovered from a heart and kidney transplant recipient[1635], and in infection in premature newborns[854]. Other unpublished isolations are from pubic white piedra, sputum, skin lesions, and blood. This species is the most frequent associated with disseminated disease[925]. The species also biotransforms biphenyl with the formation of novel ring cleavage products[2103].
FTL* in vitro susceptibility data
| AMB | ITRA | FLU | 5FC | VORI | KETO | CAS |
|---|---|---|---|---|---|---|
| 0.06 µg/ml=1 | <0.0015 µg/ml=1 | 0.25 µg/ml=1 | 4.0 µg/ml=1 | 0.03 µg/ml=1 | 0.06 µg/ml=1 | 8.0 µg/ml=1 |
| 0.25 µg/ml=4 | 0.03 µg/ml=1 | 0.5 µg/ml=1 | >64 µg/ml=1 | 0.25 µg/ml=1 | 0.25 µg/ml=1 | 16 µg/ml=1 |
| 0.5 µg/ml=1 | 0.125 µg/ml=2 | 1.0 µg/ml=1 | 0.5 µg/ml=1 | 32 µg/ml=1 | ||
| 1.0 µg/ml=1 | 2.0 µg/ml=2 | |||||
| 2.0 µg/ml=1 | 8.0 µg/ml=1 |
| Drug/N | AMB/8 | ITRA/4 | FLU/6 | 5FC/2 | VORI/3 | KETO/2 | CAS/3 |
|---|---|---|---|---|---|---|---|
| MIC Range | 0.06-2.0 | <0.015-0.125 | 0.25-8.0 | 4.0->64 | 0.03-0.5 | 0.06-0.25 | 8.0-32 |
* Fungus Testing Laboratory unpublished data (CLSI M27-A2)