Background Therapeutic drug monitoring (TDM) involves measuring and interpreting drug concentrations in biological fluids (typically serum) and applying well-described pharmacokinetic and pharmacodynamic principles of the drug to optimize a treatment regimen for an individual patient [2197]. Typically, four criteria must be fulfilled to justify the use of serum drug concentrations to guide drug dosing: First, an assay with appropriate sensitivity, specificity and “turnaround time” from the clinical laboratory must be available for analysis of the drug in question. Second, the clinical efficacy or toxicity of the drug must be delayed or difficult to directly measure. Third, the drug must exhibit […]
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