History: We present a 69-year-old male with a history of hypertension and a prior history of COVID-19 infection one year ago, who presented to the ER with persistent symptoms of headache, sinus pressure, and progressive left-sided visual loss for one year.

An 88-year-old female with hemochromatosis and cirrhosis presented with persistent left-sided otalgia, decreased hearing, and occipital headaches for several months.

A 69-year-old man with a history of stage IIIB esophageal adenocarcinoma status post chemoradiation presented with a hydropneumothorax complicated by a polymicrobial multidrug resistant empyema.

A 28-year-old man from North Carolina presents with headaches, expressive aphasia, and seizures eight months after diagnosis with Cryptococcus neoformans meningitis. Regarding his initial presentation with Cryptococcus meningitis, he presented with dyspnea, difficulty walking, and expressive aphasia.

History: A 26-year-old healthy female presented to Infectious Diseases for evaluation of a rash that had been present for over one year. The rash first started when she traveled to Bangladesh and had sexual intercourse with a male partner who had a rash on his genitals and buttocks.

A 71-year-old man with a history of sarcoidosis complicated by multisystem involvement (liver, spleen, lung, brain, and lymph nodes), who had been maintained on prednisone (10 mg daily) and adalimumab, presented to our medical facility in late fall with a 3-month (m) history of progressive fatigue and weight loss. 

The patient’s post-transplant course was complex and was most recently (starting in Spring of 2023) complicated by Tandem heart placement for worsening heart failure, bioprosthetic mitral valve replacement, PEA cardiac arrest (requiring about 5 days of  VA-ECMO), AKI needing CRRT, placement of tracheostomy, and pulmonary Mycobacterium abscessus infection.

Mucormycosis is a rare, life-threatening opportunistic infection predominantly affecting the immunocompromised population. In this case, we report a 68-year-old female with no discernible immunocompromising condition, apart from uncontrolled diabetes. She tested positive for influenza A viral infection, accompanied by methicillin-sensitive Staphylococcus aureus (MSSA) pneumonia, and subsequently unfolding pulmonary mucormycosis without rhino-cerebral involvement.

A 47-year-old man with suspected acute leukemia due to leukocytosis, thrombocytopenia, fatigue and night sweats was transferred from an outside hospital to our Department of Hematology for further diagnostics and treatment.

Title: Necrotizing pancreatitis with invasive candidiasis and candidemia due to Candida albicans and pan-echinocandin-resistant Candida glabrata Submitted by: Laman Rahimli MD, Jon Salmanton-García PhD, Prof. Oliver A. Cornely MD, Jannik Stemler MD Institution: University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Cologne, Germany andUniversity of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany. Email: laman.rahimli@uk.koeln.de Date Submitted:  13 March 2023 History:  A 64-year-old man presented to the central emergency department (day 0) with weakness and loss of sensation in his left […]

A 58-year-old male presented to our health system’s walk-in orthopedic clinic complaining of worsening pain and swelling of the third 3rd digit of his left hand.

A 41-year-old man with past medical history of diabetes mellitus type II, osteomyelitis s/p right above knee amputation, myocardial infarction s/p AICD placement, and hypertension presented with a three-day history of worsening headaches, photophobia, fever, and right hip pain.

A 39-year-old female with a past medical history of HTN, morbid obesity, chronic rhinosinusitis, s/p bilateral functional endoscopic sinus surgery (FESS) 8 months ago, presented with a 2-month history of worsening frontal headaches, accentuated by standing position and were accompanied by altered sense of smell and nausea. 

A 70-year-old gentleman was admitted to a German Military Hospital in early January 2022 with multiple lacerations of the head and retrograde amnesia following a fall at his nursing home.

A 59-year-old man was admitted for orthotopic heart transplantation. His past medical history was notable for non-ischemic cardiomyopathy status post implantable cardiac defibrillator (ICD) and prior sternotomy for implantation of a left ventricular assist device (LVAD).

A 54-year-old man status post remote orthotopic heart transplantation for non-ischemic cardiomyopathy complicated by cardiac allograft vasculopathy was admitted for redo orthotopic heart transplantation. 

A 36 year old man presented with progressively worsening headache, associated emesis and new onset altered mental status a few days after being discharged following a prolonged and complex hospitalization for cocaine overdose.

56-year-old man was admitted to an outside hospital with fever, short of breath and hypoxia. COVID-19 was diagnosed in the emergency room. He was treated with remdesivir and dexamethasone along with ceftriaxone and azithromycin. 

A 59-year-old man was admitted to a different hospital in Maryland, USA in January 2021 with bilateral pneumonia and diagnosed with COVID-19

Case #5: COVID-19 and Pulmonary Aspergillus

66-year-old white male admitted to the hospital for COVID-19 pneumonia with a two-week history of worsening shortness of breath, fevers, myalgias, anosmia, nausea and poor oral intake.

Case #4: Covid-19 and Candidemia

 A 63-year-old male who was transferred from an outside Hospital for acute hypoxic respiratory failure secondary to COVID-19 initially to the regular hospital floor service then later to the medical intensive care unit (MICU) within 24 hours of arrival. For 10 days prior to admission the patient has been experiencing generalized body aches, subjective intermittent fever with associated cough and progressively worsening shortness of breath. 

78 yo male, COVID+, worsening SOB. Recent hx: Transferred from OSH for worsening SOB, +CoVID 8 days prior to transfer.

Case #2: COVID-19 and Aspergillosis.

50-year-old male, shortness of breath, dry cough, fever and worsening hypoxia

 Case #1: COVID-19 and Pulmonary Aspergillus.

63-year-old male, presents with shortness of breath and positive SARS-CoV 2 (Covid).

A 66-year-old woman presented with exertional dyspnea, leg edema, pretibial skin hemorrhages and subjectively perceived deterioration of her general condition. The medical history included hypothyroidism. The peripheral blood analysis at admission to hospital showed pancytopenia (Hgb 8.4 g/dl, WBC 3.03 x 10*9/l, platelets 28 x 10*9/l) as well as the presence of 46% of blasts. The results of the bone marrow puncture on the following day confirmed the diagnosis of acute myeloid leukemia (AML). The baseline CT of the thorax five days after admission to hospital showed a small round focus within the right lower lung lobe.

63 year old male, presents with shortness of breath and positive SARS-CoV 2 (COVID-19).

A previously healthy 63-year-old male with no significant PMH presented to the emergency department as a level 2 trauma transfer from an outside hospital after sustaining a tree trunk injury to his left lower extremity earlier in the afternoon, resulting in significant swelling.

A 59-year-old man was admitted with five days of diffuse body pain involving shoulders, arms, legs, chest, and back associated with fatigue and generalized weakness.

A 70-year-old female with acute myeloid leukemia (AML) and prolonged neutropenia, status post 5 cycles of azacitidine and venetoclax, presented to the emergency department with two days of swelling around the left eye and progressively worsening pain of the eye, especially with eye movement.